I kēia mau lā, ua paʻi ʻia ʻo Desulfovibrio Vulgaris (Desulfovibrio Vulgaris), kahi ʻakika acetic kiʻekiʻe e hana ana i ka maʻi bacteria, i paʻi ʻia ma ka pūnaewele ma ka nūpepa honua o Microbiology e Gut Microbes (Apana 1). ʻO ka maʻi acetic acid-producing bacteria, attenuates non alcoholic fatty ate ate maʻiʻiole.

ʻO ka maʻi ate momona ʻole waiʻona (NAFLD) ka maʻi maʻi maʻamau maʻamau, a i kēia manawa aia nō ka nele o nā lāʻau lapaʻau kūpono. Ua hōʻike ʻia kahi helu nui o nā haʻawina he mea nui ka maʻi microbiota intestinal i ka pathogenesis o nā maʻi metabolic e pili ana i ka momona. No laila, ʻo ka ʻimi ʻana i ka hoʻoponopono microbiota intestinal i manaʻo ʻia he hoʻolālā hou koʻikoʻi no ka pale ʻana a me ka mālama ʻana i nā maʻi metabolic.

ʻO Polsaccharides he ʻano o nā pūhui macromolecular kūlohelohe i laha nui ʻia i ka lāʻau lapaʻau Kuʻuna Kina. Ua hōʻike ʻia kahi helu nui o nā haʻawina he hopena koʻikoʻi nā polysaccharides kanu i ka hoʻoponopono metabolism, akā ʻaʻole maopopo loa ka mīkini pololei. Ua hōʻike ka hui o Houkai Li i nā haʻawina mua e hiki i ka astragalus membranaceus polysaccharides, ka hapa nui o ka astragalus membranaceus, ke hoʻomaikaʻi i ka momona a me ka NAFLD, a nānā i ka hopena hoʻoponopono o ASTRagalus membranaceus polysaccharides ma nā pua ʻōpū a me nā metabolites ma o ka metagenomic i hui pū ʻia me ka metabonomic analysis. Ua manaʻo ʻia ke kuhiakau axis o "drug-intestinal microbiota - metabolite - host metabolism" e hoʻomaikaʻi i ka hoʻokumu ʻana o NAFLD e APS.

Ma muli o kēia kuhiakau ʻepekema, ua ʻimi ka pūʻulu noiʻi i nā bacteria ʻokoʻa a me nā metabolites pili i hoʻoponopono ʻia e APS ma o ka hoʻolālā hui pū ʻana o multi-omics, a ʻike ʻia ʻo ka hoʻomaikaʻi ʻana o NAFLD e APS ʻaʻole wale nā ​​hiʻohiʻona o ka hilinaʻi flora, akā hiki ke hoʻonui nui i ka ʻōpū. bacteria (Desulfovibrio Vulgaris). Ua hōʻoia ʻia nā haʻawina hou aʻe ʻaʻole he mea hana H2S maoli ka hua bacteria, akā loaʻa nō hoʻi ka mana kūpono e hana i ka acetic acid. ʻO ka hoʻonui nui ʻana o kēia maʻi bacteria i hoʻomaikaʻi nui i ka steatosis hepatic, ka ʻike insulin a me ka loaʻa ʻana o ke kaumaha i nā ʻiole i hānai ʻia i ka meaʻai momona. Ma o ka nānā 'ana i ka RNA SEQ a me ka noi'i biology molecular, ua hō'oia 'ia ua pili ka ho'omaika'i 'ana i ka NAFLD i ka pale 'ana o ka ate FASN a me ka hō'ike protein CD36. Ua hāʻawi kēia haʻawina i nā hōʻike hou e wehewehe i ke ʻano o ka APS i ka hoʻomaikaʻi ʻana i ka NAFLD, a hāʻawi pū i kahi kuhikuhi no ka ʻimi ʻana i ke ʻano o ka APS i ka hoʻoponopono ʻana i ka flora intestinal a me ka hoʻomaikaʻi ʻana i ka metabolism host me ke kōkua o ka ʻenehana multiomics.

Ua kōkua ʻia ka ʻikepili o nā ʻāpana astragalus polysaccharide monosaccharide i loko o kēia haʻawina e ka hui ʻo Professor Ding Kan mai Shanghai Institute of Materia Medica, Chinese Academy of Sciences, a ua kākoʻo ikaika ʻia nā metabolomics a me ka hoʻolālā kumuhana e ka hui o Professor Jia Wei mai The Sixth People's Hospital pili. i Shanghai Jiao Tong University. ʻO Ningning Zheng lāua ʻo Wei Jia nā mea kākau like o ka pepa. ʻO Hong Ying, he moho kauka no ka hui ʻo Polopeka Li Houkai, ʻo ia ka mea kākau mua o ka pepa, a ʻo Shanghai University of Traditional Chinese Medicine ka mea kākau inoa mua o ka pepa. Ua kākoʻo ʻia ka noiʻi e ka National Natural Science Research Foundation o Kina.